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APMPPE

Introduction

APMPPE typically affects 20-50s of equal gender bias
- Comes with plaque-likes lesion that resolves 2/52
- Initially unilateral, progressing to be bilateral
- Associated with HLA-B7 and HLA-DR2

It is an inflammatory condition predominantly affecting the RPE

Dead Giveaways

Symptoms:

  • Can occasionally be asymptomatic, which is a unique feature


Fundus Appearance:

  • Cream coloured placoid lesions found at the posterior pole. Possible disc inflammation, periphlebitis, disc NV and/or exudative retinal detachment.

  • Typically, hypo-FAF followed by hyper-FAF at the posterior pole, along with papillitis

    From AOA. Shows the multiple placoid lesions, and the swelling of the optic disc. This is probably papillitis
    From AOA. Shows the multiple placoid lesions, and the swelling of the optic disc. This is probably papillitis
    FAF shows placoid lesions to be hypofluorescent in the acute stages, but becomes hyper-fluorescent as they regress.
    FAF shows placoid lesions to be hypofluorescent in the acute stages, but becomes hyper-fluorescent as they regress.

OCT Appearance:

  • Hyper-reflectivity of the outer retinal layers are seen with focal disruption of EZ, and/ore RPE with some outer retinal cysts

    Shows some hypo-reflective regions and loss of EZ. REP thinning also seen. Cystic spaces are also seen on the right. SRF can thus be present.
    Shows some hypo-reflective regions and loss of EZ. REP thinning also seen. Cystic spaces are also seen on the right. SRF can thus be present.

diagnostic features

Symptoms:

  • Has the other classic WDS symptoms


Prognosis:

  • Resolves spontaneously (3-6 weeks). Good prognosis unless recurrent disease, or patient is over 60y, or macula is affected

2025, made by Eric Qin. UNSW. SOVS

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