Introduction
A rare malignancy involving high-grade diffuse extranodal large B-cell lymphomas.
- Most commonly develops in older populations (50-60y)
- Commonly bilateral
Dead Giveaways
Diagnostic Consensus:
A diagnostic consensus has been developed
Uveitis Masquerade
PVRL will commonly masquerade as uveitis, manifesting with some conditions found in chronic uveitis
Some common mimicked features include the pseudohypopyon and vitreal flare
Flare-like 
Pseudohypopyon. Can be present in other conditions like Rb
Differential from Uveitis
Anterior chamber typically doesn't show flare
There may be keratic precipitates but typically are not granulomatous
By Sobolewska B. Shows small KP and large tumour cells mimicking granulomatous KP No synechiae forms, and thus glaucoma is mosts likely not present
The appearance of the fundus shows creamy subretinal infiltrates
Creamy Lesion
diagnostic features
Risk And Prognosis
Is non-responsive to uveitic therapy
Whilst 25% of primary CNS lymphoma develop PVRL, 65-90% of PVRL develop CNS complications, which can be very fatal
Features and Symptoms:
Decreased vision and floaters
Vitreous cells, choroidal/retinal infiltrates, CNS involvement